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Title:
PEG化およびジグリコシル化されたエリスロポエチン
Document Type and Number:
Japanese Patent JP2005509609
Kind Code:
A
Abstract:
This invention is directed to an erythropoietin mutein having in vivo biological activity for causing bone marrow cells to increase production of reticulocytes and red blood cells, in that the mutein is N-glycosylated at Asn38 and Asn83 but not N-glycosylated at Asn24. Such muteins have improved pharmaceutical properties.

Inventors:
Tisher, Wilhelm
Application Number:
JP2003532536A
Publication Date:
April 14, 2005
Filing Date:
September 20, 2002
Export Citation:
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Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C12P21/02; A61K38/22; A61K47/48; A61P7/06; C07K14/505; C12N15/12; A61K38/00; (IPC1-7): C07K14/505; A61K38/22; A61P7/06; C12P21/02
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda