Title:
触媒組成物および鏡像異性体富化基質の脱富化におけるそれらの使用
Document Type and Number:
Japanese Patent JP2008517989
Kind Code:
A
Abstract:
There is provided a process for the de-enrichment of enantiomerically enriched compositions which comprises reacting an enantiomerically enriched composition comprising at least a first enantiomer or diastereomer of a substrate comprising a carbon-heteroatom bond, wherein the carbon is a chiral centre and the heteroatom is a group V heteroatom, in the presence of a catalyst system and optionally a reaction promoter to give a product composition comprising first and second enantiomers or diastereomers of the substrate having a carbon-heteroatom bond, the ratio of second to first enantiomer or diastereomer in the product composition being greater than the ratio of second to first enantiomer or diastereomer in the enantiomerically enriched composition. Preferred catalyst systems include transition metal halide complex of the formula MnXpYr wherein M is a transition metal; X is a halide; Y is a neutral optionally substituted hydrocarbyl complexing group, a neutral optionally substituted perhalogenated hydrocarbyl complexing group, or an optionally substituted cyclopentadienyl complexing group; and n, p and r are integers. The reaction promoter is preferably a halide salt.
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Inventors:
Bratzker, Andrew Jiyoung
Machine Jiyoung, Stalin
Machine Jiyoung, Stalin
Application Number:
JP2007538511A
Publication Date:
May 29, 2008
Filing Date:
October 27, 2005
Export Citation:
Assignee:
NPIL Pharmaceuticals(UK)Limited
International Classes:
C07C209/00; C07C211/27; C07B55/00; C07B61/00; C07D217/04
Attorney, Agent or Firm:
Heikichi Odashima