Title:
健康増進剤製造のための、ベタインおよび/またはコリンと組み合わせたグアニジノ酢酸(塩)の使用
Document Type and Number:
Japanese Patent JP2010521420
Kind Code:
A
Abstract:
The use of guanidinoacetic acid and/or salts thereof in combination with choline and/or betaine to produce an agent for improving brain function, bone growth and the mineralization of bones, for improving cartilage growth, for alleviating aging processes, for strengthening the immune system, as an antioxidative and neuroprotective agent, for lowering the cholesterol and triglyceride value, for preventing inflammatory processes and for lowering the blood sugar level in humans and vertebrates is described. In this connection it has surprisingly turned out that the new agents have a considerably higher bioavailability and are thus better taken up into the cells than was previously known when using creatine.
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Inventors:
Thomas Gastner
Hans-Peter Climmer
Hans-Peter Climmer
Application Number:
JP2009547579A
Publication Date:
June 24, 2010
Filing Date:
January 23, 2008
Export Citation:
Assignee:
AlzChem Trostberg GmbH
International Classes:
A61K31/198; A23K1/16; A23L1/305; A61K9/08; A61K9/14; A61K9/16; A61K9/20; A61K9/48; A61K31/14; A61K31/205; A61K31/525; A61K45/00; A61P3/06; A61P3/10; A61P19/00; A61P25/28; A61P29/00; A61P39/06; A61P43/00; A61P3/00; A61P3/02
Domestic Patent References:
| JP2001120226A | 2001-05-08 | |||
| JP2001131065A | 2001-05-15 |
Foreign References:
| US2761807A | 1956-09-04 |
Other References:
JPN5010002251; Ｂｏｒｓｏｏｋ，Ｈ． ｅｔ ａｌ．: 'Ｔｈｅ Ｂｉｏｃｈｅｍｉｃａｌ Ｂａｓｉｓ ｏｆ Ｂｅｔａｉｎｅ-Ｇｌｙｃｏｃｙａｍｉｎｅ Ｔｈｅｒａｐｙ' Ａｎｎ． Ｗｅｓｔ． Ｍｅｄ． Ｓｕｒｇ． Ｖｏｌ．５，Ｎｏ．１０, 195110, Ｐ．８２５-８２９
JPN6014009203; Ｗｙｓｓ，Ｍ．，ｅｔ ａｌ．: 'ＣＯＭＭＥＮＴＡＲＹ"ＨＥＡＬＴＨ ＩＭＰＬＩＣＡＴＩＯＮＳ ＯＦ ＣＲＥＡＴＩＮＥ： ＣＡＮ ＯＲＡＬ ＣＲＥＡＴＩＮＥ ＳＵＰＰＬＥＭＥＮＴＡＴＩＯＮ ＰＲＯＴＥＣＴ ＡＧＡＩＮＳＴ ＮＥＵＲＯ' Ｎｅｕｒｏｓｃｉ． Ｖｏｌ．１１２，Ｎｏ．２, 20020618, Ｐ．２４３-２６０
JPN6014009201; Ｒａｅ，Ｃ．，ｅｔ ａｌ．: '"Ｏｒａｌ ｃｒｅａｔｉｎｅ ｍｏｎｏｈｙｄｒａｔｅ ｓｕｐｐｌｅｍｅｎｔａｔｉｏｎ ｉｍｐｒｏｖｅｓ ｂｒａｉｎ ｐｅｒｆｏｒｍａｎｃｅ： ａ ｄｏｕｂｌｅ-ｂｌｉｎｄ， ｐｌａｃｅｂｏ-ｃｏｎｔ' Ｐｒｏｃ． Ｒ． Ｓｏｃ． Ｌｏｎｄ． Ｂ Ｂｉｏｌ． Ｓｃｉ． Ｖｏｌ．２７０，Ｎｏ．１５２９, 20031022, Ｐ．２１４７-２１５０
JPN6014009203; Ｗｙｓｓ，Ｍ．，ｅｔ ａｌ．: 'ＣＯＭＭＥＮＴＡＲＹ"ＨＥＡＬＴＨ ＩＭＰＬＩＣＡＴＩＯＮＳ ＯＦ ＣＲＥＡＴＩＮＥ： ＣＡＮ ＯＲＡＬ ＣＲＥＡＴＩＮＥ ＳＵＰＰＬＥＭＥＮＴＡＴＩＯＮ ＰＲＯＴＥＣＴ ＡＧＡＩＮＳＴ ＮＥＵＲＯ' Ｎｅｕｒｏｓｃｉ． Ｖｏｌ．１１２，Ｎｏ．２, 20020618, Ｐ．２４３-２６０
JPN6014009201; Ｒａｅ，Ｃ．，ｅｔ ａｌ．: '"Ｏｒａｌ ｃｒｅａｔｉｎｅ ｍｏｎｏｈｙｄｒａｔｅ ｓｕｐｐｌｅｍｅｎｔａｔｉｏｎ ｉｍｐｒｏｖｅｓ ｂｒａｉｎ ｐｅｒｆｏｒｍａｎｃｅ： ａ ｄｏｕｂｌｅ-ｂｌｉｎｄ， ｐｌａｃｅｂｏ-ｃｏｎｔ' Ｐｒｏｃ． Ｒ． Ｓｏｃ． Ｌｏｎｄ． Ｂ Ｂｉｏｌ． Ｓｃｉ． Ｖｏｌ．２７０，Ｎｏ．１５２９, 20031022, Ｐ．２１４７-２１５０
Attorney, Agent or Firm:
Toshio Yano
Toshiomi Yamazaki
Takuya Kuno
Hiroshi Sugimoto
Takahashi
Kimihiro Hoshi
Hiroyasu Ninomiya
Einzel Felix-Reinhard
Toshiomi Yamazaki
Takuya Kuno
Hiroshi Sugimoto
Takahashi
Kimihiro Hoshi
Hiroyasu Ninomiya
Einzel Felix-Reinhard