イムノフィリンおよびカルシウムチャネル活性を調整するためのイムノフィリンリガンドおよび方法

Title:

イムノフィリンおよびカルシウムチャネル活性を調整するためのイムノフィリンリガンドおよび方法

Document Type and Number:

Japanese Patent JP2010521419

Kind Code:

A

Abstract:

Immunophilin ligands and their uses as modulators of calcium channel activity are disclosed. Screening, therapeutic and prophylactic methods for conditions associated with calcium channel dysfunction, e.g., neurodegenerative and cardiovascular disorders, are also disclosed.

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Inventors:

Graziani, Edmund Idriss
Luang, Ben Fan
Pon, kevin
Bowlby, mark robert

Application Number:

JP2009547211A

Publication Date:

June 24, 2010

Filing Date:

January 29, 2007

Export Citation:

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Assignee:

Weiss LRC

International Classes:

C07K14/47; A61K31/539; A61K45/00; A61K45/06; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P13/10; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P43/00; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/071; C12N5/079; C12N5/10; C12N15/09; C12Q1/02; G01N33/15; G01N33/50

Domestic Patent References:

JPH0859696A

1996-03-05

Foreign References:

WO1996012018A2	1996-04-25
WO2006068932A2	2006-06-29

Other References:

JPN6012046020; Ａｎｎｕａｌ　Ｒｅｖｉｅｗ　ｏｆ　ＩｍｍｕｎｏｌｏｇｙＶｏｌ．　１４, 1996, ｐｐ．４８３-５１０
JPN6012046018; Ａｍｅｒｉｃａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｐｈｙｓｉｏｌｏｇｙ　-　Ｒｅｎａｌ　ＰｈｙｓｉｏｌｏｇｙＶｏｌ．　２９０, 2006, ｐｐ．Ｆ１２５３-Ｆ１２５９
JPN6012046022; Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．　４９, 2006, ｐｐ．４０５９-４０７１

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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