Title:
水溶性ポリエン複合体
Document Type and Number:
Japanese Patent JP4228052
Kind Code:
B2
Abstract:
A method for producing a substantially stable water-soluble polysaccharide conjugate of a polyene antibiotic is described. The method comprises the following steps: (a) activating the polysaccharide to a dialdehyde by periodate oxidation; (b) purifying the dialdehyde from interfering anions and by-products; (c) coupling the polyene to the purified dialdehyde by Schiff base formation to form the conjugate; and (d) purifying the conjugate. In a preferred embodiment, the conjugate of step (c) is reduced to an amine conjugate by a reducing agent prior to purification. Also described are imine and amine polysaccaride conjugates of the polyene Nystatin.
Inventors:
Linda, Galina
Dombu, Abraham Jei
Porachiek, Yitzhak
Benita, Simon
Dombu, Abraham Jei
Porachiek, Yitzhak
Benita, Simon
Application Number:
JP50762296A
Publication Date:
February 25, 2009
Filing Date:
August 16, 1995
Export Citation:
Assignee:
YISSUM RESEARCH DEVELOPMENT COMPANY PF THE HEBREW UNIVERSITY OP JERUSALEM
Hadjid Medical Research Services and Development Limited
Hadjid Medical Research Services and Development Limited
International Classes:
C08B37/00; A61K31/7042; A61K31/721; A61K47/48; A61P31/04; C08B37/02
Domestic Patent References:
| JP52108016A | ||||
| JP63264427A | ||||
| JP60226819A | ||||
| JP5186502A |
Foreign References:
| GB978170B |
Other References:
旧東ドイツ国審査済登録特許第87778号(DD-87778-A)
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro