Title:
【発明の名称】繊維芽細胞増殖因子15
Document Type and Number:
Japanese Patent JPH11506919
Kind Code:
A
Abstract:
Disclosed is a human Fibroblast growth factor 15 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for stimulating revascularization, for treating wounds and prevent neuronal damage. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
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Inventors:
Green, John M
Rosen, Craig A.
Rosen, Craig A.
Application Number:
JP50036496A
Publication Date:
June 22, 1999
Filing Date:
June 05, 1995
Export Citation:
Assignee:
HUMAN GENOME SCIENCES, INC.
International Classes:
C12N15/09; A61K38/22; A61K39/395; A61K45/00; A61K48/00; A61P7/02; A61P9/08; A61P9/10; A61P25/00; A61P25/28; A61P35/00; A61P43/00; C07K14/50; C07K16/22; C12N5/10; C12N15/00; C12N15/12; C12P21/02; A61K38/00; C12R1/91; (IPC1-7): C12N15/09; A61K38/22; A61K39/395; A61K45/00; A61K48/00; C07K14/50; C07K16/22; C12N5/10; C12P21/02
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)