Title:
4AAARYLLOCTAHYDROO1HH22 PYRIDINES
Document Type and Number:
Japanese Patent JPS5356669
Kind Code:
A
Abstract:
A procedure for the preparation of a cis compound of the general formula: **(See formula)** where R'1 is hydrogen, C1-C8 alkyl or **(See formula)** R4 and R5 are independently hydrogen, C1-C3 alkyl, or halogen; n is 0, 1, 2, or 3; m is 0 or 1, with the exception that when m is 0, n is other than 0; X is CO, CHOH, CH = CH, S u 0, except that when n is 0, X is different from S or O; and R2 is hydrogen, hydroxy or C1-C3 alkoxy; and its non-toxic and pharmaceutically acceptable acid addition salts; whose procedure is characterized by reacting a compound of the general formula: **(See formula)** where R'1 and R2 are as defined above, with a reducing agent, optionally cleaving the compounds of formula (II) where R'1 is C1-C8 alkyl or **(See formula)** to obtain the compounds of formula (II) where R'1 is hydrogen and optionally deesterify the compounds of formula (II) where R2 is C1-C3 alkoxy to obtain the compounds of formula (II) where R2 is hydroxy. (Machine-translation by Google Translate, not legally binding)
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Inventors:
DENISU EMU TSUINMAAMAN
Application Number:
JP13211177A
Publication Date:
May 23, 1978
Filing Date:
November 02, 1977
Export Citation:
Assignee:
LILLY CO ELI
International Classes:
A61K31/435; A61K31/451; C07D211/04; A61K31/452; A61K31/4525; A61P25/04; A61P29/00; A61P29/02; C07C45/00; C07C45/68; C07C49/757; C07D221/02; C07D221/04; C07D311/94; (IPC1-7): A61K31/435; C07D221/04
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