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Title:
COX-2標的造影剤
Document Type and Number:
Japanese Patent JP2007524630
Kind Code:
A
Abstract:
The presently disclosed subject matter provides a method for synthesizing a radiological imaging agent by reacting a COX-2-selective ligand with a compound comprising a detectable group, wherein the COX-2-selective ligand is a derivative of a non-steroidal anti-inflammatory drug (NSAID) comprising an ester moiety or a secondary amide moiety. Also provided are compositions that are synthesized using the method, as well as methods of using the compositions of the presently disclosed subject matter.

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Inventors:
Laurence J. Marnet
Sergey Timofeveski
Daniel Prudd Homme
Application Number:
JP2006517674A
Publication Date:
August 30, 2007
Filing Date:
June 25, 2004
Export Citation:
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Assignee:
VANDERBILT UNIVERSITY
International Classes:
A61K51/00; A61K49/00; A61K49/04; A61K49/08; A61K49/10; A61K51/04; C07D209/14; C07D209/18; C07D209/26; C07D209/28; C07D231/12; C07D487/04
Domestic Patent References:
JP2000510816A2000-08-22
Attorney, Agent or Firm:
Toru Ishikawa



 
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