Title:
CELL
Document Type and Number:
Japanese Patent JP2022002546
Kind Code:
A
Abstract:
To provide a cell in which a first chimeric antigen receptor (CAR) and a second CAR are co-expressed on a cell surface, in which each CAR includes an antigen binding domain, an antigen binding domain of the first CAR binds to CD19, and an antigen binding domain of the second CAR binds to CD22.SOLUTION: A cell can be an immune effector cell such as a T-cell or a natural killer (NK) cell. The properties regarding T-cell cited in this specification equally applies to other immune effector cells such as the NK cell.SELECTED DRAWING: None
Inventors:
MARTIN PULE
SHAUN CORDOBA
SHIMOBI ONUOHA
SIMON THOMAS
SHAUN CORDOBA
SHIMOBI ONUOHA
SIMON THOMAS
Application Number:
JP2021170769A
Publication Date:
January 11, 2022
Filing Date:
October 19, 2021
Export Citation:
Assignee:
AUTOLUS LTD
International Classes:
C12N15/62; A61K35/17; A61P35/00; C07K14/705; C07K16/30; C07K19/00; C12N5/10; C12N15/12; C12N15/13; C12N15/63; C12N15/867; C12P21/02
Domestic Patent References:
| JP6633081B2 | 2020-01-22 |
Foreign References:
| WO2013123061A1 | 2013-08-22 | |||
| WO2014124143A1 | 2014-08-14 |
Other References:
CURRENT HEMATOLOGIC MALIGNANCY REPORTS, vol. 9, JPN6019031588, 2 February 2014 (2014-02-02), pages 50 - 56, ISSN: 0005029187
MOLECULAR THERAPY, vol. 21, no. 11, JPN5017011269, November 2013 (2013-11-01), pages 2087 - 2101, ISSN: 0005029188
RIET, TOBIAS, ERHOHUNG DER ANTIGEN-SELEKTIVITAT VON T-ZELLEN DURCH KOEXPRESSION CHIMARER ANTIGEN-REZEPTOREN UNTERS, JPN6019031594, 2010, ISSN: 0005029189
JOURNAL OF CLINICAL IMMUNOLOGY, vol. 32, JPN5017011268, 17 April 2012 (2012-04-17), pages 1059 - 1070, ISSN: 0005029190
IMMUNOTHERAPY, vol. 3, no. 1, JPN5017011270, January 2011 (2011-01-01), pages 33 - 48, ISSN: 0005029191
CANCER IMMUNOLOGY RESEARCH, vol. 1, no. 1, JPN5017011271, 7 April 2013 (2013-04-07), pages 43 - 53, ISSN: 0005029192
MOLECULAR THERAPY, vol. 21, no. 11, JPN5017011269, November 2013 (2013-11-01), pages 2087 - 2101, ISSN: 0005029188
RIET, TOBIAS, ERHOHUNG DER ANTIGEN-SELEKTIVITAT VON T-ZELLEN DURCH KOEXPRESSION CHIMARER ANTIGEN-REZEPTOREN UNTERS, JPN6019031594, 2010, ISSN: 0005029189
JOURNAL OF CLINICAL IMMUNOLOGY, vol. 32, JPN5017011268, 17 April 2012 (2012-04-17), pages 1059 - 1070, ISSN: 0005029190
IMMUNOTHERAPY, vol. 3, no. 1, JPN5017011270, January 2011 (2011-01-01), pages 33 - 48, ISSN: 0005029191
CANCER IMMUNOLOGY RESEARCH, vol. 1, no. 1, JPN5017011271, 7 April 2013 (2013-04-07), pages 43 - 53, ISSN: 0005029192
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto