COMPOSITIONS AND METHODS FOR TREATMENT OF TYPE 1 DIABETES

Title:

COMPOSITIONS AND METHODS FOR TREATMENT OF TYPE 1 DIABETES

Document Type and Number:

Japanese Patent JP2019080574

Kind Code:

A

Abstract:

To provide compositions and methods for treating insulin-dependent diabetes mellitus.SOLUTION: The present invention provides a self-vector having a nucleic acid sequence at least 95% identical to a nucleic acid sequence of a self-vector (BHT-3021) encoding and expressing human proinsulin (hINS), and a composition that is endotoxin free and comprises an adjuvant as a pharmaceutically acceptable carrier and the self-vector, and a method for treating or preventing insulin-dependent diabetes mellitus, which comprises the step of administering the self-vector intramuscularly.SELECTED DRAWING: Figure 1

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Inventors:

BART O ROEP
ROBINSON WILLIAM H
UTZ PAUL
HIDEKI GARREN
STEINMAN LAWRENCE

Application Number:

JP2019017697A

Publication Date:

May 30, 2019

Filing Date:

February 04, 2019

Export Citation:

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Assignee:

TOLERION

International Classes:

A61K35/76; C12N15/85; A61K48/00; A61P3/10; C12N15/17

Attorney, Agent or Firm:

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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