化合物 - Spero Therapeutics Incorporated

Title:

化合物

Document Type and Number:

Japanese Patent JP7488774

Kind Code:

B2

Abstract:

The invention provides a polymyxin compound of formula (I) and salts, solvates and protected forms thereof, pharmaceutical compositions comprising the compounds of formula (I), and the use of the compounds and compositions in methods of treatment, such as methods for the treatment of microbial infections. The compounds of formula (I) are represented thus:wherein -R¹⁵ is a group:and -R¹⁶ is hydrogen; -R¹⁷ is hydrogen; -L- is a covalent bond or methylene; and -Ar is optionally substituted aryl. The groups -X-, -R¹, -R², -R³, -R⁴, and -R⁸ are as defined herein.

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Inventors:

Brown, pamela
Dawson, Michael
Simonovic, Mona
Volks, Stephen
Duparchy, Esther
Reverse, Dean
Leicester, Roy
Coleman, Scott

Application Number:

JP2020571762A

Publication Date:

May 22, 2024

Filing Date:

June 25, 2019

Export Citation:

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Assignee:

Spero Therapeutics Incorporated

International Classes:

C07K7/62; A61K38/08; A61P31/00; A61P31/04

Domestic Patent References:

JP2017538692A
JP2017510570A
JP2014533678A

Foreign References:

WO2012168820A1

Other References:

Journal of Medicinal Chemistry,2013年,Vol.56,p.5079-5093

Attorney, Agent or Firm:

Osamu Yamamoto
Toru Miyamae
Junichi Matsuo
Reiko Izumitani

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