Title:
神経内分泌腫瘍の治療における二重標的化のための合成物および方法
Document Type and Number:
Japanese Patent JP7440087
Kind Code:
B2
Abstract:
Chemical compositions and methods of synthesis thereof. The compositions disclosed and described herein are directed toward thyroid hormone αvβ3 integrin receptor antagonists conjugated to targets of the norepinephrine transporter (NET) or the catecholamine transporter. The compositions have a dual targeting effect and increased targeting efficiency in the treatment and diagnostic imaging of neuroendocrine tumors.
Inventors:
musa shaker
Rajavi, Mahdi
Karakus, Ozlem O.
Rajavi, Mahdi
Karakus, Ozlem O.
Application Number:
JP2020555772A
Publication Date:
February 28, 2024
Filing Date:
April 03, 2019
Export Citation:
Assignee:
NANOPHARMACEUTICALS, LLC
International Classes:
C07D249/04; A61K31/4192; A61K47/10; A61K47/54; A61K49/00; A61K51/02; A61P25/00; A61P35/00; A61P43/00; C08L71/02; C08L101/00
Foreign References:
| US20170348425 | ||||
| US20100255108 | ||||
| US20130224115 |
Other References:
Bioorganic & Medicinal Chemistry Letters,2018年,28(7),pp.1223-1227
Attorney, Agent or Firm:
Tomiga Konishi