Title:
DIADENOSINETETRAPHOSPHORIC ACID TETRASODIUM SALT DODECAHYDRATE CRYSTAL
Document Type and Number:
Japanese Patent JP3487939
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new compound having extremely low hygroscopic property and extremely stable physical properties and thereby, not influenced by environmental humidity in storage and capable of readily handling as medicine or its raw material and widely utilizing.
CONSTITUTION: This diadenosinetetraphosphoric acid tetrasodium salt dodecahydrate crystal is expressed by the formula. The compound is obtained by reacting, e.g. adenosine-5'-triphosphoric acid with an amino acid in the presence of an aminoacyl-tRNA synthetase to afford diadenosinetetraphosphoric acid, purifying the reaction solution using an anionic exchange resin, adding a hydrophilic organic solvent such as an alcohol or acetone, preferably in 30-50% concentration to the purified solution to carry out crystallization and filtering and drying the resultant crystals.
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Inventors:
Tatsuo Katayama
Yoshihiro Nishikawa
Mayumi Hayashi
Hiroshi Nakajima
Masahiro Ozaki
Daiichi Watanabe
Yoshihiro Nishikawa
Mayumi Hayashi
Hiroshi Nakajima
Masahiro Ozaki
Daiichi Watanabe
Application Number:
JP295195A
Publication Date:
January 19, 2004
Filing Date:
January 11, 1995
Export Citation:
Assignee:
Unitika Ltd.
International Classes:
C12P19/36; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7076; A61K31/7084; A61P3/00; A61P7/02; A61P43/00; C07H19/20; C07H19/207; C07H21/02; (IPC1-7): C07H19/207
Domestic Patent References:
JP3167126A | ||||
JP62278992A | ||||
JP53144599A |
Attorney, Agent or Firm:
Toshio Nishizawa
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