Title:
Ｆａｂ型抗体の分泌量を増大できるＦｄ鎖遺伝子又はＬ鎖遺伝子
Document Type and Number:
Japanese Patent JP6465794
Kind Code:
B2
Abstract:
It is an object of the present invention to provide a method for producing a low-molecular-weight antibody such as a Fab-type antibody, using yeast as a host, wherein the method is able to produce the low-molecular-weight antibody with high productivity. According to the present invention, there is provided a gene comprising a nucleotide sequence encoding an amino acid or an amino acid sequence capable of increasing the secretion amount of a Fab-type antibody at the 3'-terminus of a nucleotide sequence encoding the amino acid sequence of the Fd chain or L chain of an antibody.
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Inventors:
Nishiyama Tozo
Application Number:
JP2015513720A
Publication Date:
February 06, 2019
Filing Date:
April 17, 2014
Export Citation:
Assignee:
Kaneka Corporation
International Classes:
C12N15/81; C12N1/19; C12P21/08
Domestic Patent References:
| JP63503274A | ||||
| JP2007215471A | ||||
| JP2013055935A | ||||
| JP7503124A | ||||
| JP3280884A | ||||
| JP3501321A |
Foreign References:
| WO2012102171A1 |
Other References:
J.Biochem.,2001年,vol.129,no.1,p.5-12
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes