Title:
ストレスタンパク質を含む組成物を使用する免疫応答
Document Type and Number:
Japanese Patent JP4484969
Kind Code:
B2
Abstract:
The present invention relates to a vaccine for inducing an immune response to an antigen in a vertebrate (e.g., mammal) comprising an antigen and all or a portion of a stress protein or all or a portion of a protein having an amino acid sequence sufficiently homologous to the amino acid sequence of the stress protein to induce the immune response against the antigen. In a particular embodiment, the present invention relates to vaccines and compositions which induce a CTL response in a mammal comprising an antigen and all or a portion of a stress protein. In another embodiment, the invention relates to vaccines and compositions which induce an immune response to an influenza virus in a mammal comprising an antigen of the influenza virus and all or a portion of one or more stress proteins. The invention also relates to vaccines and compositions for inducing a CTL response to a tumor-associated antigen comprising a tumor-associated antigen and all or a portion of the stress protein. The invention also relates to vaccines and composition for suppressing allergic immune responses to allergens comprising an allergen and all or a portion of a stress protein.
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Inventors:
Mizen, Lee
Anthony, Lawrence S. D.
Anthony, Lawrence S. D.
Application Number:
JP52408198A
Publication Date:
June 16, 2010
Filing Date:
November 25, 1997
Export Citation:
Assignee:
Nuventa By Offer Mastical Corporation
International Classes:
A61K39/145; C12N15/09; A61K39/04; A61K39/35; A61K47/48; C07K14/11; C07K14/35; C07K19/00; C12P21/02; A61K38/00; A61K39/00
Domestic Patent References:
| JP8510756A | ||||
| JP2000507083A |
Foreign References:
| WO1997006821A1 | ||||
| WO1997026910A1 | ||||
| WO1995024923A1 |
Other References:
Eur. J. Immunol., 1992年, Vol.22, p.1365-72
Curr. Opin. Immunol., 1994年, Vol.6, p.728-32
Curr. Opin. Immunol., 1994年, Vol.6, p.728-32
Attorney, Agent or Firm:
Hidesaku Yamamoto