IMPROVED FIBRONECTIN-BASED BINDING MOLECULES AND USES THEREOF

Title:

IMPROVED FIBRONECTIN-BASED BINDING MOLECULES AND USES THEREOF

Document Type and Number:

Japanese Patent JP2018118978

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide monoclonal antibody-substituting binding molecules that specifically bind to a target of interest with high affinity and specificity.SOLUTION: Disclosed herein is a bispecific Fn3-based binding molecule comprising a first non-Fn3 binding sequence and a second non-Fn3 binding sequence, where, in the first non-Fn3 binding sequence at least one amino acid is altered in at least one of the bottom AB, CD or EF loop regions or the C terminal of the first non-Fn3 binding sequence compared to the wild type Fn3 domain, and the first non-Fn3 binding sequence binds to a frist target, and in the second non-Fn3 binding sequence, at least one amino acid is altered in at least one of the top BC, DE, or FG loop regions of the Fn3 domain compared to the wild type Fn3 domain, and the second non-Fn3 binding sequence binds to a second target where the first and second targets are present on different molecules.SELECTED DRAWING: None

Inventors:

JOHN HASTEWELL
ANDREAS LOEW

Application Number:

JP2018037151A

Publication Date:

August 02, 2018

Filing Date:

March 02, 2018

Export Citation:

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Assignee:

NOVARTIS AG

International Classes:

C07K19/00; A61K38/36; A61K38/39; A61K39/395; A61K47/60; A61K47/64; A61K47/65; A61K47/69; A61P29/00; A61P35/00; A61P37/06; C07K14/725; C07K14/78; C07K16/00

Domestic Patent References:

JP2004502451A	2004-01-29
JP2007516707A	2007-06-28

Other References:

PROTEIN ENGINEERING, vol. 15, no. 12, JPN5011002908, 1 January 2002 (2002-01-01), pages 1015 - 1020, ISSN: 0004145264

Attorney, Agent or Firm:

Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Yoshimitsu Maki
Yasuhito Suzuki

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