INHIBITION OF INFLAMMATION USING ALPHA 7 RECEPTOR-BINDING CHOLINERGIC AGONIST

Title:

INHIBITION OF INFLAMMATION USING ALPHA 7 RECEPTOR-BINDING CHOLINERGIC AGONIST

Document Type and Number:

Japanese Patent JP2011105745

Kind Code:

A

Abstract:

To provide treating of various conditions using a cholinergic agonist which has selectivity in an α7 nicotinic receptor.

The use of a cholinergic agonist which has selectivity in an α7 nicotinic receptor in a sufficient amount to decrease the amount of an inflammatory cytokine released from a macrophage in medicinal preparation for treating an inflammatory condition is disclosed, wherein the condition is selected from the group consisting of appendicitis, digestive organ nature ulcer, gastric ulcer and duodenal ulcer, peritonitis, pancreatitis, epiglottitis, achalasia, choledochitis, cholecystitis, hepatitis, Whipple's disease, asthma, allergy, anaphylactic shock, immune complex disease, internal organs necrosis, hay fever, sepsis, septicemia, endotoxin shock, vicious liquid, hyperpyrexia, eosinophilic granuloma, granulomatosis, sarcoidosis, septic abortion, epididymitis, vaginitis, prostatitis, urethritis, bronchitis, pulmonary emphysema, rhinitis, cystic fibrosis, pneumonia or the like.

Inventors:

TRACEY KEVIN J
WANG HONG

Application Number:

JP2011014401A

Publication Date:

June 02, 2011

Filing Date:

January 26, 2011

Export Citation:

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Assignee:

LONG ISLAND JEWISH RES INST

International Classes:

A61K45/00; A61K31/00; A61K31/439; A61K31/444; A61K31/46; A61P1/00; A61P9/00; A61P11/00; A61P15/00; A61P29/00; A61P31/00; A61P33/00; A61P37/00; A61P43/00; C07D213/53; C07D453/02; C07D498/20; G01N33/68; G01N33/94

Domestic Patent References:

JPH10504561A	1998-05-06
JP2001510194A	2001-07-31
JP4750421B2	2011-08-17
JP2004528307A	2004-09-16
JP2005512507A	2005-05-12

Foreign References:

WO2002044176A1	2002-06-06
WO2002030405A2	2002-04-18
WO1999010338A2	1999-03-04
WO2002016358A2	2002-02-28
WO2001089526A1	2001-11-29

Other References:

JPN6009066126; ＦＲＡＮＣＩＳ　ＭＭ，　ｅｔ　ａｌ．: 'Ｓｐｅｃｉｆｉｃ　ａｃｔｉｖａｔｉｏｎ　ｏｆ　ｔｈｅ　ａｌｐｈａ　７　ｎｉｃｏｔｉｎｉｃ　ａｃｅｔｙｌｃｈｏｌｉｎｅ　ｒｅｃｅｐｔｏｒ　ｂｙ　ａ　ｑｕａｔｅｒｎａｒｙ　ａｎａｌｏｇ　ｏｆ　ｃｏｃａｉｎ' Ｍｏｌｅｃｕｌａｒ　ＰｈａｒｍａｃｏｌｏｇｙＶｏｌ．　６０，　Ｎｏ．　１, 2001, ｐ．　７１-７９

Attorney, Agent or Firm:

Yoshinori Hosoda

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