Title:
METHODS AND COMPOSITIONS FOR REDUCING METASTASES
Document Type and Number:
Japanese Patent JP2021105060
Kind Code:
A
Abstract:
To provide methods and compositions for reducing metastases.SOLUTION: The subject matter described herein is directed to methods of modifying the micro-environment of a target cell. The methods comprise the step of systemically administering to a subject a composition comprising a vector, where the vector comprises a construct for the expression of a trap in the target cell, and the trap is expressed in the target cell, thereby modifying the micro-environment. Also described herein are methods of reducing metastasis of a cancer comprising the step of systemically administering to a subject suffering from the cancer, a composition comprising a vector, where the vector comprises a construct for the expression of a trap, the trap is delivered to and then expressed in tissue susceptible to metastasis, and metastasis of the cancer to the tissue is reduced. Compositions for carrying out the methods are also described.SELECTED DRAWING: None
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Inventors:
LEAF HUANG
TYLER GOODWIN
LIU RIHE
MIAO LEI
TYLER GOODWIN
LIU RIHE
MIAO LEI
Application Number:
JP2021072064A
Publication Date:
July 26, 2021
Filing Date:
April 21, 2021
Export Citation:
Assignee:
UNIV NORTH CAROLINA CHAPEL HILL
International Classes:
A61K31/7088; A61K9/127; A61K35/12; A61K35/15; A61K35/545; A61K35/76; A61K38/16; A61K39/395; A61K47/24; A61K47/34; A61K47/44; A61K48/00; A61P1/00; A61P1/18; A61P5/00; A61P19/00; A61P35/00; A61P35/04; A61P43/00; C07K14/705; C07K14/78; C07K16/24; C07K19/00; C12N15/12; C12N15/13; C12N15/62; C12N15/63
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto