Title:
鏡像異性体富化基質の脱富化方法
Document Type and Number:
Japanese Patent JP2008517990
Kind Code:
A
Abstract:
There is provided a process for the de-enrichment of enantiomerically enriched compositions which comprises reacting an enantiomerically enriched composition comprising at least a first enantiomer or diastereomer of a substrate comprising a carbon-heteroatom bond, wherein the carbon is a chiral centre and the heteroatom is a group VI heteroatom, in the presence of a catalyst system and optionally a reaction promoter to give a product composition comprising first and second enantiomers or diastereomers of the substrate having a carbon-heteroatom bond, the ratio of second to first enantiomer or disatereomer in the product composition being greater than the ratio of second to first enantiomer or disatereomer in the enantiomerically enriched composition. Preferred substrates include compounds of Formula (1) wherein: X represents O, S; R1, R2 each independently represents an optionally substituted hydrocarbyl, a perhalogenated hydrocarbyl, an optionally substituted heterocyclyl group; or R1 & R2 are optionally linked in such a way as to form an optionally substituted ring(s); provided that R1 and R2are selected such that * is a chiral centre. In a preferred process a compound of Formula : (2) wherein: X represents O, S; R1, R2 each independently represents an optionally substituted hydrocarbyl, a perhalogenated hydrocarbyl, an optionally substituted heterocyclyl group; or R1 & R2 are optionally linked in such a way as to form an optionally substituted ring(s); provided that R1 and R2 are different, may be obtained.
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Inventors:
Bratzker, Andrew Jiyoung
Machine Jiyoung, Stalin
Machine Jiyoung, Stalin
Application Number:
JP2007538513A
Publication Date:
May 29, 2008
Filing Date:
October 27, 2005
Export Citation:
Assignee:
NPIL Pharmaceuticals(UK)Limited
International Classes:
C07C29/143; B01J31/22; B01J31/26; C07B55/00; C07C29/00; C07C33/22; C07C45/29; C07C49/78; C07B61/00
Attorney, Agent or Firm:
Heikichi Odashima