Title:
NEW METHOD FOR IDENTIFYING BINDING-SITE DOMAIN RETAINING CAPACITY OF BINDING TO EPITOPE
Document Type and Number:
Japanese Patent JP2009148280
Kind Code:
A
Abstract:
To provide a method for identifying a domain having binding affinity for a preselected epitope.
The method for identifying a binding-site domain that retains the capacity of binding to an epitope when positioned at the C-terminal of at least one further domain in a recombinant bi- or multivalent polypeptide, is provided. A kit is also provided, comprising components such as panels of recombinant vectors of bacterial libraries transfected with recombinant vectors. Furthermore, binding site domains and fusion proteins as well as antibody-like molecules comprising such domains and proteins are provided. Besides, pharmaceutical and diagnostic compositions containing the fusion proteins and polypeptides are provided.
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Inventors:
KUFER PETER
RAUM TOBIAS
BORSCHERT KATRIN
ZETTL FLORIAN
LUTTERBUESE RALF
RAUM TOBIAS
BORSCHERT KATRIN
ZETTL FLORIAN
LUTTERBUESE RALF
Application Number:
JP2009034882A
Publication Date:
July 09, 2009
Filing Date:
February 18, 2009
Export Citation:
Assignee:
MICROMET AG
International Classes:
C12N15/09; G01N33/566; A61K38/00; A61K38/22; A61K38/43; A61K39/395; A61P35/00; A61P37/06; C07K14/705; C07K16/18; C07K16/30; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/10; C12N15/13; C12N15/62; C12P21/02; C12P21/08; C40B40/02; G01N33/53; G01N33/577
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes