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Title:
PRODUCTION OF HETEROCYCLIC AROMATIC CARBOXYLIC ACID ARYLAMIDE
Document Type and Number:
Japanese Patent JPH1017552
Kind Code:
A
Abstract:

To obtain the subject compound, to start with a readily available material, by reaction of a heterocyclic aromatic halogen compound with carbon monoxide and an aromatic amine in the presence of a catalyst and a base.

This compound, an amide of formula I [A1 is N or CR1; A2 is N or CR2; A3 is N or CR3; A4 is N or CR4; A5 is N or CR5 (R1 to R5 are each H, a 1-4C alkyl, aryl, etc.); R6 is H or a 1-4C alkyl; R7 is a (substituted) aromatic or heterocyclic aromatic group], is obtained by reaction of a halide of formula II (X is Cl, Br or I) with carbon monoxide and an amine of the formula R6-NH-R7 in the presence of a base and a complex of a diphosphine of formula III [R8 to R11 are each a (substituted) phenyl; (n) is 3 or 4] and palladium. The diphosphine is pref. 1,3-bis(diphenylphosphino)propane or 1,4-bis(diphenylphosphino)butane.


Inventors:
JEAN-PAUL RODUIT
GEORGES KALBERMATTEN
Application Number:
JP6856697A
Publication Date:
January 20, 1998
Filing Date:
March 21, 1997
Export Citation:
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Assignee:
LONZA AG
International Classes:
B01J31/24; C07B61/00; C07D213/81; C07D213/82; C07D213/803; C07D239/34; C07D239/42; C07D241/24; C07D253/06; (IPC1-7): C07D213/803; B01J31/24
Attorney, Agent or Firm:
Sou Suga