Title:
PRODUCTION OF POLYSACCHARIDE DERIVATIVE MONOMER
Document Type and Number:
Japanese Patent JP3148029
Kind Code:
B2
Abstract:
PURPOSE: To obtain the subject monomer capable of providing a polymer useful as a new substrate for cell culture, a biodegradable plastic, etc., due to vinyl group at the reducing terminal of a polysaccharide by (co)polymerization, etc., according to a specific method using an oligosaccharide as a raw material.
CONSTITUTION: The aldehyde in a reducing terminal site of an oligosaccharide (e.g. maltopentaose) having 3-10 polymerization degree is initially oxidized with e.g. iodine to form a lactone, which is then made to react with a compound, expressed by formula I (R is a compound in which C, H, N, etc., are bound through covalent bond) and having vinyl group and amino group together (preferably vinylbenzylamine, etc.) to form the amide bond between the lactone site of the oligosaccharide and the amino group site of the compound expressed by formula I. An enzyme (e.g. a phosphorylase) is finally made to act on the bound polysaccharide site having 3-10 polymerization degree until a polysaccharide having 15-500 number-average polymerization degree is prepared. Thereby, the objective monomer expressed by formula II [(n) is ≥13] is obtained.
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Inventors:
Issei Kobayashi
Naoki Enomoto
Sachiko Furukawa
Yasushi Ogasawara
Hirofumi Akano
Yoshiya Kawamura
Naoki Enomoto
Sachiko Furukawa
Yasushi Ogasawara
Hirofumi Akano
Yoshiya Kawamura
Application Number:
JP35879792A
Publication Date:
March 19, 2001
Filing Date:
December 28, 1992
Export Citation:
Assignee:
Daicel Chemical Industry Co., Ltd.
International Classes:
C07H15/04; C08B11/15; C08F290/02; C08F299/00; C12P19/26; (IPC1-7): C12P19/26; C07H15/04; C08B11/15
Attorney, Agent or Firm:
Fujiro Kubota