Title:
HUMAN HOMOLOGUES OF FUSED GENE
Document Type and Number:
WIPO Patent Application WO2000063352
Kind Code:
A3
Abstract:
This invention relates to novel molecules, in particular nucleic acid sequences and the encoded polypeptides, which are the human homologues of the protein-serine/threonine kinase named Fused. The molecules of the inventions are involved in the transduction of the signal in the Hedgehog-Patched (HH-PTCH) pathway.
Inventors:
MOSCA MONICA (IT)
ISACCHI ANTONELLA (IT)
ISACCHI ANTONELLA (IT)
Application Number:
PCT/EP2000/002761
Publication Date:
February 01, 2001
Filing Date:
March 29, 2000
Export Citation:
Assignee:
PHARMACIA & UPJOHN SPA (IT)
MOSCA MONICA (IT)
ISACCHI ANTONELLA (IT)
MOSCA MONICA (IT)
ISACCHI ANTONELLA (IT)
International Classes:
G01N33/50; A61K38/00; A61K39/395; A61K45/00; A61P35/00; C07K14/47; C07K16/18; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12N15/09; C12N15/54; C12P21/08; C12Q1/48; C12Q1/68; G01N33/15; G01N33/53; G01N33/577; (IPC1-7): C12N9/12; A61P35/00; C07K16/28; C07K16/40; C12N15/54; C12N15/63; C12N15/86; C12Q1/68; G01N33/50
Domestic Patent References:
| WO1999043828A1 | 1999-09-02 | |||
| WO1999032609A1 | 1999-07-01 | |||
| WO1999053058A1 | 1999-10-21 |
Other References:
HILLIER ET AL.: "Generation and analysis of 280,000 human expressed sequence tags", EMBL SEQUENCE DATABASE, 25 July 1996 (1996-07-25), HEIDELBERG DE, XP002153110
BLANCHET-TOURNIER M -F ET AL: "The segment-polarity gene 'fused' is highly conserevd in Drosophila", GENE,ELSEVIER BIOMEDICAL PRESS. AMSTERDAM,NL, vol. 161, 1995, pages 157 - 162, XP002109761, ISSN: 0378-1119
THÉROND P P ET AL: "Phosphorylation of the fused protein kinase in response to signaling from hedgehog", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,NATIONAL ACADEMY OF SCIENCE. WASHINGTON,US, vol. 93, April 1996 (1996-04-01), pages 4224 - 4228, XP002109762, ISSN: 0027-8424
CARPENTER D ET AL: "Characterization of two patched receptors for the vertebrate hedgehog protein family", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 95, no. 23, 10 November 1998 (1998-11-10), pages 13630 - 13634, XP002101428, ISSN: 0027-8424
ZAPHIROPOULOS P G ET AL: "PTCH2, a novel human patched gene undergoing alternative splicing and up-regulated in basal cell carcinomas", CANCER RESEARCH,AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD,US, vol. 59, 15 February 1999 (1999-02-15), pages 787 - 792, XP002109560, ISSN: 0008-5472
NAGASE ET AL.: "Prediction of the coding sequence of unidentified human genes. XV. The complete sequence of 100 new cDNA clones from brain which code for large proteins in vitro", EMBL SEQUENCE DATABASE, 11 November 1999 (1999-11-11), HEIDELBERG DE, XP002153111
BLANCHET-TOURNIER M -F ET AL: "The segment-polarity gene 'fused' is highly conserevd in Drosophila", GENE,ELSEVIER BIOMEDICAL PRESS. AMSTERDAM,NL, vol. 161, 1995, pages 157 - 162, XP002109761, ISSN: 0378-1119
THÉROND P P ET AL: "Phosphorylation of the fused protein kinase in response to signaling from hedgehog", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,NATIONAL ACADEMY OF SCIENCE. WASHINGTON,US, vol. 93, April 1996 (1996-04-01), pages 4224 - 4228, XP002109762, ISSN: 0027-8424
CARPENTER D ET AL: "Characterization of two patched receptors for the vertebrate hedgehog protein family", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 95, no. 23, 10 November 1998 (1998-11-10), pages 13630 - 13634, XP002101428, ISSN: 0027-8424
ZAPHIROPOULOS P G ET AL: "PTCH2, a novel human patched gene undergoing alternative splicing and up-regulated in basal cell carcinomas", CANCER RESEARCH,AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD,US, vol. 59, 15 February 1999 (1999-02-15), pages 787 - 792, XP002109560, ISSN: 0008-5472
NAGASE ET AL.: "Prediction of the coding sequence of unidentified human genes. XV. The complete sequence of 100 new cDNA clones from brain which code for large proteins in vitro", EMBL SEQUENCE DATABASE, 11 November 1999 (1999-11-11), HEIDELBERG DE, XP002153111
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