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Title:
INHIBITORS OF ACK1/TNK1 TYROSINE KINASE
Document Type and Number:
WIPO Patent Application WO/2022/036310
Kind Code:
A3
Abstract:
The present disclosure provides anti-cancer compounds and uses thereof, more particularly inhibitors of ACK1 tyrosine kinase and their use in the treatment of cancer.

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Inventors:
LAWRENCE NICHOLAS J (US)
LAWRENCE HARSHANI RITHMA (US)
DUCKETT DEREK (US)
REUTHER GARY (US)
Application Number:
PCT/US2021/046112
Publication Date:
March 10, 2022
Filing Date:
August 16, 2021
Export Citation:
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Assignee:
H LEE MOFFITT CANCER CT & RES (US)
International Classes:
C07D471/18; C07D487/04; C07D487/12
Domestic Patent References:
WO2010055117A12010-05-20
Foreign References:
US20170044111A12017-02-16
US20180215738A12018-08-02
US20190315726A12019-10-17
Other References:
TAN ET AL.: "Development of Selective Covalent Janus Kinase 3 Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, 10 August 2015 (2015-08-10), pages 6589 - 6606, XP055573287, DOI: 10.1021/acs.jmedchem.5b00710
Attorney, Agent or Firm:
ANDREANSKY, Eric S. et al. (US)
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