Title:
METHODS AND IMMUNE MODULATORY NUCLEIC ACID COMPOSITIONS FOR PREVENTING AND TREATING DISEASE
Document Type and Number:
WIPO Patent Application WO2004047734
Kind Code:
A3
Abstract:
This invention relates to methods and compositions for treating or preventing disease comprising the administration of immune modulatory nucleic acids having one or more immune modulatory sequences (IMSs). The invention further relates to the means and methods for the identification of the IMSs for preventing or treating disease, more particularly the treatment and prevention of autoimmune or inflammatory diseases. The invention also relates to the treatment or prevention of disease comprising the administration of the immune modulatory nucleic acids alone or in combination with a polynucleotide encoding self-protein(s), -polypeptide(s) or -peptide(s). The present invention also relates to methods and compositions for treating diseases in a subject associated with one or more self-protein(s), -polypeptide(s) or -peptide(s) that are present in the subject and involved in a non-physiological state.
More Like This:
Inventors:
GARREN HIDEKI (US)
HO PEGGY P (US)
STEINMAN LAWRENCE (US)
HO PEGGY P (US)
STEINMAN LAWRENCE (US)
Application Number:
PCT/US2003/037157
Publication Date:
August 12, 2004
Filing Date:
November 21, 2003
Export Citation:
Assignee:
BAYHILL THERAPEUTICS INC (US)
UNIV LELAND STANFORD JUNIOR (US)
GARREN HIDEKI (US)
HO PEGGY P (US)
STEINMAN LAWRENCE (US)
UNIV LELAND STANFORD JUNIOR (US)
GARREN HIDEKI (US)
HO PEGGY P (US)
STEINMAN LAWRENCE (US)
International Classes:
A61K31/70; A61K31/715; A61K48/00; (IPC1-7): A61K48/00; A61K31/70; A61K31/715; A01N43/04; C07H21/04; C07H21/02
Foreign References:
| US6225292B1 | 2001-05-01 | |||
| US6194388B1 | 2001-02-27 | |||
| US20020164341A1 | 2002-11-07 | |||
| US20030181406A1 | 2003-09-25 |
Other References:
ZEUNER ET AL: "Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides", ARTHRITIS AND RHEUMATISM, vol. 46, no. 8, August 2002 (2002-08-01), pages 2219 - 2224, XP002965005
HO ET AL: "An immunomodulatory CpG oligonucleotide for the treatment of autoimmunity via the innate and adaptive immune systems", J. IMMUNOLOGY, vol. 171, 2003, pages 4920 - 4926, XP002977880
STACEY ET AL: "Immunostimulatory DNA as an adjuvant in vaccination against Leishmania major", IFECTION AND IMMUNITY, vol. 67, no. 8, August 1999 (1999-08-01), pages 3719 - 3726, XP002977881
HO ET AL: "An immunomodulatory CpG oligonucleotide for the treatment of autoimmunity via the innate and adaptive immune systems", J. IMMUNOLOGY, vol. 171, 2003, pages 4920 - 4926, XP002977880
STACEY ET AL: "Immunostimulatory DNA as an adjuvant in vaccination against Leishmania major", IFECTION AND IMMUNITY, vol. 67, no. 8, August 1999 (1999-08-01), pages 3719 - 3726, XP002977881
Download PDF: