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WIPO Patent Application WO2006067450

A3

The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein R¹ and R² are each independently H or alkyl; Y is an alkyl group, CONR³R⁴, COOR⁵ SO₂NR¹⁶R¹⁷, NHSO₂R¹⁸ or CN; X is an aryl or heteroaryl group, each of which may be optionally substituted with one or more substituents selected from (CH2)_mZ where Z is halogen, OH, CN, alkyl, alkoxy, NO₂, CF₃, CONR⁶R⁷, CN, NR⁸R⁹, COOR¹⁰ or NHCOR^11, and m is 0 to 3; R³ to R¹¹ are each independently H, alkyl or aryl, wherein said alkyl and aryl groups are optionally substituted by one or more substituents selected from halogen, OH, CN, alkyl, alkoxy, NO₂, CF₃, CONR¹²R¹³, CN, NH₂, COOR¹⁴, NHCOR¹⁵, and CN; R¹² to R¹⁸ are each independently H or alkyl, more preferably H or Me; n is 1 to 6; wherein the compound is other than 3' ,5'-dimethyl-4-(1,1-dimethylheptyl)-1,1'-biphenyl-2-ol. Further aspects of the invention relate to the use of such compounds in the preparation of a medicament for the treatment of a muscular disorder, a gastrointestinal disorder, or for controlling spasticity or tremors.

JP4245172	Pattern-forming substrate, negative resist composition, pattern-forming method, and semiconductor device
JP2010059159	2,2',6,6'-TETRAHYDROXY-3,3',5,5'-TETRASUBSTITUTED BIPHENYL LIGAND AND METHOD FOR SYNTHESIZING THE SAME
WO/1990/015041	PREPARATION OF PHENYLHYDROQUINONE

SELWOOD DAVID (GB)
VISINTIN CRISTINA (GB)
BAKER DAVID (GB)
PRYCE GARETH (GB)
OKUYAMA MASAHIRO (JP)

PCT/GB2005/004990

September 14, 2006

December 21, 2005

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UCL BIOMEDICA PLC (GB)
SELWOOD DAVID (GB)
VISINTIN CRISTINA (GB)
BAKER DAVID (GB)
PRYCE GARETH (GB)
OKUYAMA MASAHIRO (JP)

C07C39/15; A61K31/05; A61K31/055; A61K31/165; A61K31/167; A61P21/00; C07C37/055; C07C37/11; C07C37/62; C07C39/06; C07C39/27; C07C39/367; C07C45/00; C07C59/90; C07C67/343; C07C233/03; C07C233/25; C07C235/26; C07C235/34; C07D213/02; C07D213/30

WO2004017920A2	2004-03-04
WO2003091189A1	2003-11-06

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LIN, MING-YUAN ET AL: "Ruthenium-Catalyzed Cyclization of Alkyne-Epoxide Functionalities through Alternation of the Substituent and Structural Skeleton of Epoxides", JOURNAL OF ORGANIC CHEMISTRY, vol. 69, no. 22, 2004, pages 7700 - 7704, XP002386271
ONAKA, TOSHIMITSU ET AL: "Desulfurization characteristics of thermophilic Paenibacillus sp. strain A 11-2 against asymmetrically alkylated dibenzothiophenes", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 92, no. 2, 2001, pages 193 - 196, XP002386272
GAREAU Y ET AL: "Structure activity relationships of tetrahydrocannabinol analogues on human cannabinoid receptors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 2, 23 January 1996 (1996-01-23), pages 189 - 194, XP004135106, ISSN: 0960-894X

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