Title:
N-(3-METHOXY-5-METHYLPYRAZIN-2-YL)-2-(4-'1,3,4-OXADIAZOL-2-YL!PHENYL)PYRIDINE-3 SULPHONAMIDE AS AN ANTICANCER AGENT
Document Type and Number:
WIPO Patent Application WO2004018044
Kind Code:
A3
Abstract:
The use of N-(3-methoxy-5-methylpyrazin-2-yl)-2-(4-[1,3,4-oxadiazol-2-yl]phenyl)pyridine-3-sulphonamide, or a pharmaceutically acceptable salt thereof, in the treatment of cancer and/or pain in a warm blooded animal such as man is described.
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Inventors:
TONGE DAVID WILLIAM (GB)
TAYLOR SIAN TOMIKO (GB)
BOYLE FRANCIS THOMAS (GB)
HUGHES ANDREW MARK (GB)
JOHNSTONE DONNA (GB)
ASHFORD MARIANNE BERNICE (GB)
BARRASS NIGEL CHARLES (GB)
TAYLOR SIAN TOMIKO (GB)
BOYLE FRANCIS THOMAS (GB)
HUGHES ANDREW MARK (GB)
JOHNSTONE DONNA (GB)
ASHFORD MARIANNE BERNICE (GB)
BARRASS NIGEL CHARLES (GB)
Application Number:
PCT/GB2003/003653
Publication Date:
May 06, 2004
Filing Date:
August 20, 2003
Export Citation:
Assignee:
ASTRAZENECA AB (SE)
ASTRAZENECA UK LTD (GB)
TONGE DAVID WILLIAM (GB)
TAYLOR SIAN TOMIKO (GB)
BOYLE FRANCIS THOMAS (GB)
HUGHES ANDREW MARK (GB)
JOHNSTONE DONNA (GB)
ASHFORD MARIANNE BERNICE (GB)
BARRASS NIGEL CHARLES (GB)
ASTRAZENECA UK LTD (GB)
TONGE DAVID WILLIAM (GB)
TAYLOR SIAN TOMIKO (GB)
BOYLE FRANCIS THOMAS (GB)
HUGHES ANDREW MARK (GB)
JOHNSTONE DONNA (GB)
ASHFORD MARIANNE BERNICE (GB)
BARRASS NIGEL CHARLES (GB)
International Classes:
C07D413/14; A61K31/497; A61P9/00; A61P25/02; A61P25/04; A61P29/00; A61P35/00; A61P35/02; A61P35/04; A61P43/00; (IPC1-7): A61P35/00; A61P29/00; A61K31/497
Domestic Patent References:
| WO1996040681A1 | 1996-12-19 | |||
| WO2001044239A2 | 2001-06-21 | |||
| WO2002049630A2 | 2002-06-27 |
Other References:
CARDUCCI M A ET AL: "ENDOTHELIN RECEPTOR ANTAGONIST, ABT-627, FOR PROSTATE CANCER: INITIAL TRIAL RESULTS", JOURNAL OF UROLOGY, BALTIMORE, MD, US, vol. 161, no. 4, SUPPL, April 1999 (1999-04-01), pages 176, XP001037609, ISSN: 0022-5347
NELSON J B ET AL: "THE ROLE OF ENDOTHELIN-1 AND ENDOTHELIN RECEPTOR ANTAGONISTS IN PROSTATE CANCER", BJU INTERNATIONAL, BLACKWELL SCIENCE, OXFORD, GB, vol. 85, no. SUPPL 2, April 2000 (2000-04-01), pages 45 - 48, XP008007943, ISSN: 1464-4096
JARVIS M F ET AL: "ABT-627, AN ENDOTHELIN ETA RECEPTOR-SELECTIVE ANTAGONIST, ATTENUATES TACTILE ALLODYNIA IN A DIABETIC RAT MODEL OF NEUROPATHIC PAIN", EUROPEAN JOURNAL OF PHARMACOLOGY, AMSTERDAM, NL, vol. 388, no. 1, 24 January 2000 (2000-01-24), pages 29 - 35, XP001152675, ISSN: 0014-2999
DATABASE WPI Section Ch Week 200163, Derwent World Patents Index; Class B03, AN 2001-565331, XP002271565
NELSON J B ET AL: "THE ROLE OF ENDOTHELIN-1 AND ENDOTHELIN RECEPTOR ANTAGONISTS IN PROSTATE CANCER", BJU INTERNATIONAL, BLACKWELL SCIENCE, OXFORD, GB, vol. 85, no. SUPPL 2, April 2000 (2000-04-01), pages 45 - 48, XP008007943, ISSN: 1464-4096
JARVIS M F ET AL: "ABT-627, AN ENDOTHELIN ETA RECEPTOR-SELECTIVE ANTAGONIST, ATTENUATES TACTILE ALLODYNIA IN A DIABETIC RAT MODEL OF NEUROPATHIC PAIN", EUROPEAN JOURNAL OF PHARMACOLOGY, AMSTERDAM, NL, vol. 388, no. 1, 24 January 2000 (2000-01-24), pages 29 - 35, XP001152675, ISSN: 0014-2999
DATABASE WPI Section Ch Week 200163, Derwent World Patents Index; Class B03, AN 2001-565331, XP002271565
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