Title:
NEW VITAMIN D DERIVATIVES WITH CYCLIC SUBSTRUCTURES IN THE SIDE CHAINS, METHOD AND INTERMEDIATES FOR THEIR PRODUCTION AND THEIR USE IN THE PREPARATION OF MEDICAMENTS
Document Type and Number:
WIPO Patent Application WO2001007405
Kind Code:
A3
Abstract:
The invention relates to vitamin D derivatives of the formula (I), wherein Z is an optionally substituted carbocyclic or heterocyclic, optionally aromatic or heteroaromatic 5- or 6-membered ring or an optionally substituted condensed ring structure that consists of a 5-membered and a 6-membered ring or of two 6-membered rings, and Q, R1-R4, X1-X2 and Y1-Y3 have the meanings given in the description. The invention further relates to a method for their production, to the use of said derivatives in the preparation of medicaments, and to a method for producing compounds of the formula (Iia), wherein E represents any side chain, and R7, R8, Y2, Y3 and Y5 have the meanings given in the description. The invention also relates to the intermediates of both methods.
Inventors:
STEINMEYER ANDREAS
SCHWARZ KATICA
GIESEN CLAUDIA
HABEREY MARTIN
FAEHNRICH MARIANNE
SCHWARZ KATICA
GIESEN CLAUDIA
HABEREY MARTIN
FAEHNRICH MARIANNE
Application Number:
PCT/EP2000/007104
Publication Date:
March 28, 2002
Filing Date:
July 24, 2000
Export Citation:
Assignee:
SCHERING AKTIENGSELLSCHAFT (DE)
International Classes:
A61K31/59; A61K38/00; A61P3/10; A61P3/14; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P17/14; A61P19/02; A61P19/08; A61P19/10; A61P25/00; A61P25/02; A61P29/00; A61P35/00; A61P35/02; A61P37/00; B21C25/02; B21C25/10; C07C33/05; C07C69/608; C07C401/00; C07D231/14; C07D235/12; C07D263/32; C07D277/22; C07D277/24; C07D277/64; C07D307/80; C07D333/16; C07D333/22; C07D333/56; C07F7/18; C07F9/40; C07F9/53; (IPC1-7): C07C401/00
Domestic Patent References:
| WO1997041096A1 | 1997-11-06 | |||
| WO1998047866A2 | 1998-10-29 |
Foreign References:
| EP0927721A1 | 1999-07-07 | |||
| EP0717034A1 | 1996-06-19 | |||
| EP0854138A2 | 1998-07-22 |
Other References:
NEMOTO, H. ET AL.: "A Novel o-Quinodimethane Strategy for an Active Metabolite of Vitamin D3. A Total Synthesis of 25-Hydroxy Windaus-Grundmann Ketone", TETRAHEDRON LETTERS, vol. 31, no. 43, 1990, pages 6205 - 6208, XP000973072
HATAKEYAMA, S. ET AL.: "A Novel Convergent Synthesis of (+)-1alpha,25-Dihyroxyvitamin D3 Using a Chromium(II)-Mediated Coupling Reaction", JOURNAL OF ORGANIC CHEMISTRY, vol. 56, no. 1, 1991, pages 461 - 463, XP000973200
DURAISAMY, M. & WALBORSKY, H.M.: "Circular Dichroism of Isomeric 10-19-Dihydrovitamin D1", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 105, no. 10, 1983, pages 3270 - 3273, XP000973256
DODO, K. ET AL.: "Synthesis of a Novel Class of cdc25A Inhibitors from Vitamin D3", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, no. 7, 2000, pages 615 - 617, XP004191838
HATAKEYAMA, S. ET AL.: "A Novel Convergent Synthesis of (+)-1alpha,25-Dihyroxyvitamin D3 Using a Chromium(II)-Mediated Coupling Reaction", JOURNAL OF ORGANIC CHEMISTRY, vol. 56, no. 1, 1991, pages 461 - 463, XP000973200
DURAISAMY, M. & WALBORSKY, H.M.: "Circular Dichroism of Isomeric 10-19-Dihydrovitamin D1", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 105, no. 10, 1983, pages 3270 - 3273, XP000973256
DODO, K. ET AL.: "Synthesis of a Novel Class of cdc25A Inhibitors from Vitamin D3", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, no. 7, 2000, pages 615 - 617, XP004191838
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