NOVEL AMIDE DERIVATIVES - BANYU PHARMA CO LTD

Title:

NOVEL AMIDE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/2001/007406

Kind Code:

A1

Abstract:

Compounds of general formula [I] exhibiting selective antagonism against muscarinic M¿3? receptor and being useful as treatments for respiratory, urologic or digestive diseases wherein A is a group represented by general formula [a¿0?] or [b¿0?], Ar?1¿, Ar?2¿ and Ar?3¿ are each optionally substituted phenyl; k is 0 or 1; m, n and s are each 0, 1 or 2; R?1¿ is hydrogen or optionally substituted lower alkyl; R?2¿, R?3¿, R?4¿ and R?5¿ are each hydrogen, optionally substituted lower alkyl, or the like; R?60¿ is hydrogen, alkyl, or the like; R?61¿ and R?71¿ are each alkyl or the like; X is carbonyl or methylene; Y is nitrogen or methyne; and Q?-¿ is an anion.

Inventors:

SAGARA YUFU (JP)
UCHIYAMA MINAHO (JP)
NAYA AKIRA (JP)
KIMURA TOSHIFUMI (JP)
NUMAZAWA TOMOSHIGE (JP)
FUJIKAWA TORU (JP)
OTAKE NORIKAZU (JP)
NOGUCHI KAZUHITO (JP)

Application Number:

PCT/JP2000/004762

Publication Date:

February 01, 2001

Filing Date:

July 14, 2000

Export Citation:

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Assignee:

BANYU PHARMA CO LTD (JP)
SAGARA YUFU (JP)
UCHIYAMA MINAHO (JP)
NAYA AKIRA (JP)
KIMURA TOSHIFUMI (JP)
NUMAZAWA TOMOSHIGE (JP)
FUJIKAWA TORU (JP)
OTAKE NORIKAZU (JP)
NOGUCHI KAZUHITO (JP)

International Classes:

A61P1/04; A61P1/06; A61P1/08; A61P11/00; A61P13/00; A61P43/00; C07D207/16; C07D211/26; C07D401/12; C07D401/14; C07D471/10; C07D493/10; C07D498/10; (IPC1-7): C07D207/16; C07D211/26; C07D401/14; C07D401/12; C07D471/10; A61K31/401; A61K31/438; A61K31/445; A61K31/454; A61P43/00; A61P1/04; A61P1/06; A61P1/08; A61P11/00; A61P13/00

Foreign References:

EP0823423A1	1998-02-11
EP0747355A1	1996-12-11

Other References: