Title:
SMALL MOLECULES AND A PHARMACOPHORE MODEL FOR INHIBITION OF ANTHRAX LETHAL FACTOR
Document Type and Number:
WIPO Patent Application WO/2005/109304
Kind Code:
A2
Abstract:
Disclosed herein is a pharmacophore model for inhibiting anthrax lethal factor protease activity which comprises a first aromatic center A, a second aromatic center B, a first polar center C, a second polar center D, a third polar center E, and a neutral linker F. Also disclosed are small molecules fitting the pharmacophore model and compositions and methods of using thereof.
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Inventors:
BAVARI SINA (US)
PANCHAL REKHA (US)
PANCHAL REKHA (US)
Application Number:
PCT/US2004/043273
Publication Date:
November 17, 2005
Filing Date:
December 20, 2004
Export Citation:
Assignee:
US ARMY MEDICAL RES AND MATERI (US)
BAVARI SINA (US)
PANCHAL REKHA (US)
BAVARI SINA (US)
PANCHAL REKHA (US)
International Classes:
C12Q1/18; C12Q1/37; G01N33/48; G01N33/50; G06G7/48; G06G7/58; G16C20/64; (IPC1-7): G06G7/48; G06G7/58; G06F19/00; G01N33/48; G01N33/50
Other References:
'DTP-Diversity Set Information for NSC 12155', [Online] XP002995971 Retrieved from the Internet:
'DTP-Diversity Set Information for NSC 317881, NSC317884, NSC 341909, and NSC357756', [Online] Retrieved from the Internet:
PANCHAL ET AL.: 'Identification of small molecule inhibitors of anthrax lethal factor' NATURE STRUCTURAL AND MOLECULAR BIOLOGY vol. 11, no. 1, January 2004, pages 67 - 72
MONTECUCCO C. ET AL.: 'Stop the Killer: how to inhibit the anthrax letal factor metalloprotease' TRENDS IN BIOCHEMICAL SCIENCES vol. 29, no. 6, June 2004, pages 282 - 285
'DTP-Diversity Set Information for NSC 317881, NSC317884, NSC 341909, and NSC357756', [Online] Retrieved from the Internet:
PANCHAL ET AL.: 'Identification of small molecule inhibitors of anthrax lethal factor' NATURE STRUCTURAL AND MOLECULAR BIOLOGY vol. 11, no. 1, January 2004, pages 67 - 72
MONTECUCCO C. ET AL.: 'Stop the Killer: how to inhibit the anthrax letal factor metalloprotease' TRENDS IN BIOCHEMICAL SCIENCES vol. 29, no. 6, June 2004, pages 282 - 285
Attorney, Agent or Firm:
Arwine, Elizabeth (U.S. Army Medical Research & Materiel
Command 504 Scott Street, ATTN: MCMR-JA, Ms. Arwin, Fort Detrick MD, US)
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