TREATMENT OF NEURONAL DISEASES - CENTER FOR EXCELLENCE IN BRAIN SCIENCE AND INTELLIGENCE TECH CHINESE ACADEMY OF SCIENCES

Title:

TREATMENT OF NEURONAL DISEASES

Document Type and Number:

WIPO Patent Application WO/2021/032069

Kind Code:

A1

Abstract:

Methods and compositions for treating certain neurodegenerative diseases, such as RGC loss-related degenerative disease and Parkinson's Disease, using in vivo conversion of gilal cells to neurons by PTB and optionally nPTB knock down via CRISPR/Cas delivered by viral vectors (e.g., AAV vector).

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Inventors:

YANG HUI (CN)
ZHOU HAIBO (CN)

Application Number:

PCT/CN2020/109655

Publication Date:

February 25, 2021

Filing Date:

August 17, 2020

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Assignee:

CENTER FOR EXCELLENCE IN BRAIN SCIENCE AND INTELLIGENCE TECH CHINESE ACADEMY OF SCIENCES (CN)

International Classes:

C12N15/85; A61K38/17; A61P1/18; A61P25/28; C12N5/0793

Domestic Patent References:

WO2008082730A2	2008-07-10
WO2018112446A2	2018-06-21

Foreign References:

CN105950557A	2016-09-21
CN105950557A	2016-09-21
CN109777877A	2019-05-21
CN107441480A	2017-12-08
CN109913420A	2019-06-21
CN102858985A	2013-01-02
AU2007333106A1	2008-06-19

Attorney, Agent or Firm:

XU & PARTNERS, LLC. (CN)

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