AN ULTRASONIC SURGICAL INSTRUMENT FOR INTRACORPOREAL SONODYNAMIC THERAPY

WIPO Patent Application WO2003002189

A3

The present invention relates, in general, to ultrasonic surgical instruments and, more particularly, to an intracorporeal ultrasonic surgical instrument for sonodynamic therapy. Disclosed is an ultrasonic surgical system (25) comprising: a generator (10) and an instrument (50) comprising: a housing (74); a transducer (65); a semi-permeable membrane (55); a pharmaceutical agent (75); and an agent delivery system (77). The transducer (65) is adapted to convert the electrical energy of the generator into mechanical energy. The pharmaceutical agent (75), delivered into a chamber of the semi-permeable membrane (55), is driven through the semi-permeable membrane (55) by the mechanical energy. A method in accordance with the present invention comprises the steps of: providing a surgical instrument (25) comprising: a housing (74); a transducer (65) connected to the housing (74); a semi-permeable membrane (55); a pharmaceutical agent (75); and an agent delivery system (77); inserting the surgical instrument into a patient; delivering a drug to the patient; and locally activating the drug with the surgical instrument (25).

JP6561069	Receptacle portion and method of percutaneous drug delivery device
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MAKIN INDER RAJ S
JURGEN NOPPE
JOHANNES MARIA MARCUS

PCT/US2002/020431

April 10, 2003

June 27, 2002

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ETHICON ENDO SURGERY INC (US)

A61M37/00; A61B18/00; A61N7/00; (IPC1-7): A61B8/14

US5720287A	1998-02-24
US5617851A	1997-04-08
US5267985A	1993-12-07
US5762066A	1998-06-09

See also references of EP 1408838A4

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