VASCULAR PERMEATION INHIBITOR - FUJISAWA PHARMACEUTICAL CO

Title:

VASCULAR PERMEATION INHIBITOR

Document Type and Number:

WIPO Patent Application WO/1997/013509

Kind Code:

A1

Abstract:

A vascular permeation inhibitor, especially an inhibitor for, e.g., carcinomatous hydrothorax or carcinomatous ascites, which comprises an oxaspirooctane derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, and a pharmacologically acceptable carrier, wherein R1 represents, e.g., lower alkylcarbamoyl or protected carbamoyl; R2 represents lower alkoxy; and R3 represents the group represented by formula (II).

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Inventors:

SHIMOMURA KYOICHI (JP)
MANDA TOSHITAKA (JP)
NISHIGAKI FUSAKO (JP)

Application Number:

PCT/JP1996/002945

Publication Date:

April 17, 1997

Filing Date:

October 11, 1996

Export Citation:

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Assignee:

FUJISAWA PHARMACEUTICAL CO (JP)
SHIMOMURA KYOICHI (JP)
MANDA TOSHITAKA (JP)
NISHIGAKI FUSAKO (JP)

International Classes:

A61K31/336; C07D303/22; (IPC1-7): A61K31/335; C07D303/16; C07D303/20

Foreign References:

JPH0285272A	1990-03-26
JPH037222A	1991-01-14

Other References: