有機化合物

Japanese Patent JP2012526810

A

The present invention relates to a new use of phosphodiesterase 1 (PDE1) inhibitors for the treatment of psychosis, schizophrenia, schizoaffective disorder, schizophreniform disorder, psychotic disorder, delusional disorder, mania, or bipolar disorder.

JP2022084699	NOVEL MONOCYCLIC AND BICYCLIC RING SYSTEM SUBSTITUTED CARBANUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS
WO/2024/067575	NITROGEN-CONTAINING POLYCYCLIC COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
WO/2003/091256	PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND NAD(P)H OXIDASE INHIBITOR CONTAINING THE SAME

Allen A. Feinberg
Lawrence Jay Wenogle
Sharon Mates

JP2012510800A

November 01, 2012

May 13, 2010

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INTRA-CELLULAR THERAPIES, INC.

A61K31/519; A61P25/18; A61P25/22; A61P43/00; C07D487/04; C07D487/14; C07D487/20

JP2008545783A	2008-12-18
JP2009539872A	2009-11-19
JPS61236778A	1986-10-22
JPH11217383A	1999-08-10
JP2010509399A	2010-03-25

WO2007143705A2	2007-12-13
WO2008063505A1	2008-05-29

JPN6014022185; ＨＡＬＥＮＥ，　Ｔ．Ｂ．　ｅｔ　ａｌ: 'Ａｎｔｉｐｓｙｃｈｏｔｉｃ-ｌｉｋｅ　ｐｒｏｐｅｒｔｉｅｓ　ｏｆ　ｐｈｏｓｐｈｏｄｉｅｓｔｅｒａｓｅ　４　ｉｎｈｉｂｉｔｏｒｓ：　ｅｖａｌｕａｔｉｏｎ　ｏｆ　４-（３-ｂｕｔｏｘｙ-４-ｍｅｔｈｏｘｙ' Ｊ．　Ｐｈａｒｍａｃｏｌ．　Ｅｘｐ．　Ｔｈｅｒ． Ｖｏｌ．３２６，　Ｎｏ．１, 2008, ｐ．２３０-２３９
JPN6014022188; ＰＯＬＬＩ，　Ｊ．Ｗ．　ｅｔ　ａｌ: 'Ｅｘｐｒｅｓｓｉｏｎ　ｏｆ　ａ　ｃａｌｍｏｄｕｌｉｎ-ｄｅｐｅｎｄｅｎｔ　ｐｈｏｓｐｈｏｄｉｅｓｔｅｒａｓｅ　ｉｓｏｆｏｒｍ　（ＰＤＥ１Ｂ１）　ｃｏｒｒｅｌａｔｅｓ　ｗｉｔｈ　ｂｒａｉｎ　ｒｅｇｉｏｎ' Ｊ．　Ｎｅｕｒｏｓｃｉ． Ｖｏｌ．１４，　Ｎｏ．３, 1994, ｐ．１２５１-１２６１
JPN6014022191; ＡＨＮ，　Ｈ．Ｓ．　ｅｔ　ａｌ: 'Ｐｏｔｅｎｔ　ｔｅｔｒａｃｙｃｌｉｃ　ｇｕａｎｉｎｅ　ｉｎｈｉｂｉｔｏｒｓ　ｏｆ　ＰＤＥ１　ａｎｄ　ＰＤＥ５　ｃｙｃｌｉｃ　ｇｕａｎｏｓｉｎｅ　ｍｏｎｏｐｈｏｓｐｈａｔｅ　ｐｈｏｓｐｈｏｄｉｅｓｔｅｒ' Ｊ．　Ｍｅｄ．　Ｃｈｅｍ． Ｖｏｌ．４０，　Ｎｏ．１４, 1997, ｐ．２１９６-２２１０

Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai

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