5'-FLUORO-2-HYDROXYPHENONE DERIVATIVE AND ITS PREPARATION

Title:

5'-FLUORO-2-HYDROXYPHENONE DERIVATIVE AND ITS PREPARATION

Document Type and Number:

Japanese Patent JPS6178749

Kind Code:

A

Abstract:

NEW MATERIAL:5'-Fluoro-2'-hydroxyphenone derivative of formula I (R is ClCH2CH-, ClC(CHH3)HCH2-, CH2=CH-).

EXAMPLE: 8-Chloro-5'fluoro-2'-hydroxypropiophenone.

USE: A synthetic intermediate of remedy for diabetes such as (S)-6-fluoro- spiro-[chroman-4,4'-imidazolidine]-2',5'-di-one or (2R,4S)-6-Fluoro-2-methyl- spiro-[chroman-4,4'-imidazolidin-e]-2,5-dione.

PREPARATION: 4-Fluroanisol is allowed to react with an acid chloride of RCOCl to give 5'-fluoro-2'-hydroxyphenone.

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Inventors:

UEDA YASUYOSHI
TAKAHASHI SATOMI
SHIMADA YOSHIO
WATANABE KIYOSHI

Application Number:

JP20087384A

Publication Date:

April 22, 1986

Filing Date:

September 26, 1984

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Assignee:

KANEGAFUCHI CHEMICAL IND

International Classes:

C07C45/46; C07C45/00; C07C49/825; C07C49/835; C07C67/00; (IPC1-7): C07C45/46; C07C49/825; C07C49/835

Attorney, Agent or Firm:

Shinichi Asano

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