Title:
がんの検査方法及び検査用キット
Document Type and Number:
Japanese Patent JP5875054
Kind Code:
B2
Abstract:
An object of the present invention is to elucidate a molecular mechanism of ligand-independent activation of EphA2 in cancer cells, make EphA2 a more useful target in the treatment of cancer, and provide a cancer testing method and the like using the mechanism. The present invention provides, for example, a cancer testing method including a step of measuring an amount of an EphA2 protein fragment having a molecular weight of from 30 kDa to 80 kDa in a sample derived from a subject.
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Inventors:
Naohiko Koshikawa
Motoharu Seiki
Motoharu Seiki
Application Number:
JP2013206511A
Publication Date:
March 02, 2016
Filing Date:
October 01, 2013
Export Citation:
Assignee:
National University Corporation Tokyo University
International Classes:
G01N33/574; A61K31/713; A61K48/00; A61P35/00; C12Q1/37; G01N33/15; G01N33/50; G01N33/53
Domestic Patent References:
| JP2003516930A | ||||
| JP2012103264A | ||||
| JP2005532805A |
Foreign References:
| US20110281279 | ||||
| US20120122112 |
Other References:
YANG Pu et al.,Overexpression of EphA2, MMP-9, and MVD-CD34 in hepatocellular carcinoma: Implications for tumor pro,Hepatol Res,2009年12月,Vol.39, No.12, Page.1169-1177
SUGIYAMA Nami et al.,EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion,J Cell Biol,2013年 4月29日,Vol.201, No.3, Page.467-484
SUGIYAMA Nami et al.,EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion,J Cell Biol,2013年 4月29日,Vol.201, No.3, Page.467-484
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito