Title:
ジオキセタン化合物及び微生物検出のためのそれらの使用
Document Type and Number:
Japanese Patent JP7462574
Kind Code:
B2
Abstract:
A method is for the detection of presence or absence, quantification, and identification of target microorganisms, such as bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, fungi as well as other pathogens by means of chemiluminescence. The method include providing a medium with one or more target analytes, target microorganisms or target metabolites, adding a dioxetane compound to the medium so that the dioxetane compound emits light, and detecting the emitted light.
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Inventors:
Shabat, Delon
Ross Conforti, Michal Eli
Hananiya, Neil
Green, ori
Spitz, Urus
Wick, Lucas
Esen, Julian
Wolberg, Rafael
Cribiu, Ricardo
Babjakova, Zuzana
Yao, Chun Yang
Ross Conforti, Michal Eli
Hananiya, Neil
Green, ori
Spitz, Urus
Wick, Lucas
Esen, Julian
Wolberg, Rafael
Cribiu, Ricardo
Babjakova, Zuzana
Yao, Chun Yang
Application Number:
JP2020567041A
Publication Date:
April 05, 2024
Filing Date:
May 24, 2019
Export Citation:
Assignee:
Nemis Technologies Akchengesellshaft
International Classes:
C07D321/00; C07D487/04; C07H15/26; C12Q1/04; C12Q1/26; G01N33/04; G01N33/483; G01N33/579
Domestic Patent References:
| JP2020520981A | ||||
| JP2017505612A |
Foreign References:
| WO2017130191A1 | ||||
| WO2009139811A2 | ||||
| CN102183512A | ||||
| CN106279178A |
Other References:
Tal Eilon-Shaffer et al.,ortho-Chlorination of phenoxy 1,2-dioxetane yields superior chemiluminescent probes for in vitro and in vivo imaging,Organic & Biomolecular Chemistry,2018年,16,1708-1712,DOI: 10.1039/c8ob00087e
Michal E. Roth-Konforti et al.,Unprecedented Sensitivity in a Probe for Monitoring Cathepsin B: Chemiluminescence Microscopy Cell-Imaging of a Natively Expressed Enzyme,Angewandte Chemie, International Edition ,2017年,56,15633-15638,DOI: 10.1002/anie.201709347
Margret Ryan et al.,A chemiluminescent substrate for the detection of phosphatidylinositol-specific phospholipase C,Analytical Biochemistry ,1993年,214,548-56
Nir Hananya et al.,A Glowing Trajectory between Bio- and Chemiluminescence: From Luciferin-Based Probes to Triggerable Dioxetanes,Angewandte Chemie, International Edition ,2017年,56,16454-16463,DOI: 10.1002/anie.201706969
Michal E. Roth-Konforti et al.,Unprecedented Sensitivity in a Probe for Monitoring Cathepsin B: Chemiluminescence Microscopy Cell-Imaging of a Natively Expressed Enzyme,Angewandte Chemie, International Edition ,2017年,56,15633-15638,DOI: 10.1002/anie.201709347
Margret Ryan et al.,A chemiluminescent substrate for the detection of phosphatidylinositol-specific phospholipase C,Analytical Biochemistry ,1993年,214,548-56
Nir Hananya et al.,A Glowing Trajectory between Bio- and Chemiluminescence: From Luciferin-Based Probes to Triggerable Dioxetanes,Angewandte Chemie, International Edition ,2017年,56,16454-16463,DOI: 10.1002/anie.201706969
Attorney, Agent or Firm:
Patent Attorney Corporation Shuwa Patent Office
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