PULSATILE DRUG RELEASE

Japanese Patent JP2016040309

A

PROBLEM TO BE SOLVED: To provide a treatment where it is desired that an active agent is designed to be released in a pulse at a certain time point after administration of the active agent.SOLUTION: A press-coated tablet formulation is used, comprising (a) a core comprising the active agent(s) together with an excipient(s); and (b) a delayed release layer surrounding the core and comprising a wax and L-HPC in a ratio of 40:60 to 60:40 w/w. The present invention is particularly suitable for administering an agent which may be released while a subject is sleeping. As well as treating certain conditions by a particular regime, the invention also provides novel formulations for a delayed, followed by a pulsed release of drug.SELECTED DRAWING: Figure 1

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ALEXANDER MULLEN
HOWARD STEVENS
SARAH ECCLESTON

JP2015219312A

March 24, 2016

November 09, 2015

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UNIV STRATHCLYDE

A61K9/42; A61K31/437; A61K31/4985; A61K31/519; A61K45/00; A61K47/06; A61K47/14; A61K47/38; A61K47/44; A61P25/20

JP2008517970A	2008-05-29
JP2003503340A	2003-01-28

WO2009008487A1	2009-01-15
WO2009101940A1	2009-08-20

GHIMIRE: "IN-VITRO/IN-VIVO CORRELATION OF PULSATILE DRUG RELEASE FROM PRESS-COATED TABLET 以下備考", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. V67 N2, JPN5013004764, 8 August 2007 (2007-08-08), NL, pages 515 - 523, ISSN: 0003420392

Takaki Nishijima
Disciple Maru Ken
Shinichiro Tanaka
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Tomoyuki Iwasawa

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