Title:
VIRAL POLYMERASE INHIBITOR
Document Type and Number:
Japanese Patent JP2010077139
Kind Code:
A
Abstract:
To provide new serial compounds having inhibitory activity to HCV polymerase.
There are provided an isomer, enantiomer, diastereomer or tautomer of a specific indole compound represented by the formula [wherein R3 is cycloalkyl; R2 represents heterocycle such as furan or pyridine; and L represents specific amino containing nitrogen-containing heterocycle] and salts thereof, as an inhibitor of HCVNS5B polymerase.
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Inventors:
BEAULIEU PIERRE LOUIS
BROCHU CHRISTIAN
CHABOT CATHERINE
JOLICOEUR ERIC
KAWAI STEPHEN
POUPART MARC-ANDRE
TSANTRIZOS YOULA S
BROCHU CHRISTIAN
CHABOT CATHERINE
JOLICOEUR ERIC
KAWAI STEPHEN
POUPART MARC-ANDRE
TSANTRIZOS YOULA S
Application Number:
JP2009258002A
Publication Date:
April 08, 2010
Filing Date:
November 11, 2009
Export Citation:
Assignee:
BOEHRINGER INGELHEIM INT
International Classes:
C07D401/14; A61K31/404; A61K31/427; A61K31/428; A61K31/4439; A61K31/4545; A61K31/4725; A61K31/496; A61K31/506; A61K31/5377; A61K31/541; A61K31/551; A61K45/00; A61P1/16; A61P31/12; A61P43/00; C07D209/08; C07D209/30; C07D401/04; C07D401/06; C07D405/04; C07D405/14; C07D409/04; C07D409/14; C07D413/14; C07D417/04; C07D417/14; C07D513/04; C07B61/00
Domestic Patent References:
| JP2001247550A | 2001-09-11 | |||
| JP2005504030A | 2005-02-10 | |||
| JP2004537564A | 2004-12-16 | |||
| JP4585507B2 | 2010-11-24 |
Foreign References:
| WO2002004425A2 | 2002-01-17 | |||
| US6358992B1 | 2002-03-19 | |||
| US20010039286A1 | 2001-11-08 |
Other References:
JPN6009020524; ＺＨＡＮＧ，Ｈ． ｅｔ ａｌ．: 'Ｅｆｆｉｃｉｅｎｔ ｓｙｎｔｈｅｓｉｓ ｏｆ ３-ｓｕｂｓｔｉｔｕｔｅｄ ２-ａｒｙｌｉｎｄｏｌｅｓ ｖｉａ Ｓｕｚｕｋｉ ｃｏｕｐｌｉｎｇ ｒｅａｃｔｉｏｎｓ ｏｎ ａ ｓｏｌｉｄ ｐｈａｓｅ' Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．４２， Ｎｏ．２９, 2001, ｐ．４７５１-４７５４
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai