scFv RECOMBINANT ANTIBODY TO SURFACE ANTIGEN OF SPOROZOIT OF EIMERIA SP. CAUSING AVIAN COCCIDIOSIS

Japanese Patent JP2003088370

A

To provide a DNA encoding a variable region of a heavy chain and a light chain of a new antibody to a surface antigen of a sporozoit of Eimeria sp. causing avian coccidiosis.

The present invention relates to a new scFv recombinant antibody to the surface antigen of the sporozoit of Eimeria sp. causing avian coccidiosis, more particularly a new variable region of the heavy chain and the light chain especially suitable for producing scFv recombinant antibody and a scFv recombinant antibody using the same. The scFv recombinant antibody described in the present invention sufficiently exhibits a function as an antibody, shows excellent tissue permeability because of the small size thereof, can be produced in large amount through a host cell of a prokaryotic cell such as E. coli, and is available for manual immunization of the avian coccidiosis and affinity purification to an eimeria vaccine antigen.

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KIM JINKYU
HAN ZEYON
SON KIDOKU
KIM SONWON
MIN WONGI
SON UNJON
HYUN SUN RIREHOJI
ERIC PETER RIREHOJI

JP2001266333A

March 25, 2003

September 03, 2001

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AVICORE BIOTECHNOLOGY INST INC

C12N15/09; A61K38/00; A61K39/395; A61K48/00; A61P33/02; C07K16/20; C12P21/08; (IPC1-7): C12N15/09; A61K38/00; A61K39/395; A61K48/00; A61P33/02; C07K16/20; C12P21/08

JPH05317080A

1993-12-03

Yasuo Yasutomi

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