Title:
NOVEL ESTROGEN beta RECEPTOR AND ISOFORMS
Document Type and Number:
WIPO Patent Application WO1999005170
Kind Code:
A8
Abstract:
The present invention provides the amino acid and mucleotide sequence of the complete estrogen receptor beta (ER beta c) gene and related protein sequences. Based on this disclosure, the present invention provides methods for identifying agents that block or augment ER beta c mediated transcriptional regulation, methods to determine wheter ER beta c or its isoforms is being expressed in tissues or cells and methods of identifying and using agents that block the transcriptional regulation of genes by ER beta c or its isoforms, which in turn modulates other biological and pathological processes.
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Inventors:
DENTON REX (US)
GALIEN RENE (FR)
RISCHE-RIGON MICHELE (FR)
FRASION CAROLINE (FR)
GALIEN RENE (FR)
RISCHE-RIGON MICHELE (FR)
FRASION CAROLINE (FR)
Application Number:
PCT/US1998/015539
Publication Date:
April 15, 1999
Filing Date:
July 28, 1998
Export Citation:
Assignee:
UNIV YALE (US)
DENTON REX (US)
GALIEN RENE (FR)
RISCHE RIGON MICHELE (FR)
FRASION CAROLINE (FR)
DENTON REX (US)
GALIEN RENE (FR)
RISCHE RIGON MICHELE (FR)
FRASION CAROLINE (FR)
International Classes:
C12N15/09; A61K31/7088; A61K31/711; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61K51/00; A61P13/08; A61P19/10; A61P35/00; A61P43/00; C07K14/47; C07K14/705; C07K14/72; C07K16/28; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12P21/08; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566; (IPC1-7): C07K14/435; C07K14/47; C07K14/705; C12N1/21; C12N5/10; C12N15/10; C12N15/11
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