NUCLEIC ACID DELIVERY ENHANCER

WIPO Patent Application WO/2021/080020

A1

Provided is a novel anti-tumor agent capable of delivering siRNA or shRNA specifically to pancreatic cancer cells and suppressing tumor enlargement, infiltration, and metastasis of pancreatic cancer.　The present invention provides a nucleic acid delivery enhancer that is for delivering siRNA or shRNA into cells and that comprises a folate-cationic oligopeptide complex. The present invention also provides an anti-tumor agent that contains a folate-cationic oligopeptide complex and siRNA or shRNA capable of binding to mRNA or snoRNA expressed in pancreatic cancer cells to inhibit the expression. Said siRNA is capable of binding to RNA selected from the group consisting of, for example, SNORA18 snoRNA, NUP85 mRNA, WASF2 mRNA, and SNORA22 snoRNA.

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TANIUCHI KEISUKE (JP)
WADA TAKESHI (JP)
HARA RINTARO (JP)
SATO KAZUKI (JP)
TAKAGI KAZUNORI (JP)

PCT/JP2020/040071

April 29, 2021

October 26, 2020

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UNIV NAT CORP KOCHI UNIV (JP)
UNIV TOKYO SCIENCE FOUND (JP)

A61K31/7105; A61K31/713; A61K47/22; A61K47/42; A61P1/18; A61P35/00; A61P35/04; C07K7/00; C07K14/00; C12N15/113

WO2014148620A1	2014-09-25
WO2016002844A1	2016-01-07
WO2016002844A1	2016-01-07
WO2014148620A1	2014-09-25

JP2019194646A	2019-11-07
JP2018110575A	2018-07-19
JP2020078771A	2020-05-28

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See also references of EP 4049664A4

HIRAKI & ASSOCIATES (JP)

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